pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release. Keywords: drug-nanoparticle interactions; drug uptake; intra-macrophage; iron oxide nanoparticles; norfloxacin; Introduction Nanoparticles have taken

• , with reduced size or aggregation [11][13][14]. In this regard, the use of drugs as both a stabilizing agent and an antibiotic could prove to be beneficial. To this end, an understanding of drug–nanoparticle interactions can enable the identification of key parameters for optimal drug loading and drug